Why human color vision cannot reliably detect cerebrospinal fluid xanthochromia.
نویسندگان
چکیده
BACKGROUND Visual assessment of cerebrospinal fluid (CSF) for xanthochromia (yellow color) is practiced by the majority of laboratories worldwide as a means of diagnosing intracranical bleeds. METHODS Colorimetric and spectrophotometric analysis of CSF samples for recognizing the presence of bilirubin either in low concentrations or in the presence of hemolysed blood. RESULTS The experiments provide the physiological and colorimetric basis for abandoning visual assessment of CSF for xanthochromia. CONCLUSIONS We strongly recommend relying on spectrophotometry as the analytical method of choice.
منابع مشابه
Should spectrophotometry be used to identify xanthochromia in the cerebrospinal fluid of alert patients suspected of having subarachnoid hemorrhage?
BACKGROUND AND PURPOSE The absence of xanthochromia in the cerebrospinal fluid (CSF) is often used to exclude subarachnoid hemorrhage (SAH). Authorities advocate spectrophotometry to measure xanthochromia, but most North American hospitals use visual inspection. We studied the diagnostic accuracy of spectrophotometry for SAH, and its potential impact on current practice. METHODS This was a pr...
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متن کاملShould Spectrophotometry Be Used to Identify Xanthochromia in the Cerebrospinal Fluid of Alert Patients Suspected of Having Subarachnoid Hemorrhage?
Background and Purpose—The absence of xanthochromia in the cerebrospinal fluid (CSF) is often used to exclude subarachnoid hemorrhage (SAH). Authorities advocate spectrophotometry to measure xanthochromia, but most North American hospitals use visual inspection. We studied the diagnostic accuracy of spectrophotometry for SAH, and its potential impact on current practice. Methods—This was a pros...
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ورودعنوان ژورنال:
- Stroke
دوره 36 6 شماره
صفحات -
تاریخ انتشار 2005